A statistical mechanical method to optimize energy functions for protein folding
نویسندگان
چکیده
منابع مشابه
A statistical mechanical method to optimize energy functions for protein folding.
We present a method for deriving energy functions for protein folding by maximizing the thermodynamic average of the overlap with the native state. The method has been tested by using the pairwise contact approximation of the energy function and generating alternative structures by threading sequences over a database of 1, 169 structures. With the derived energy function, most native structures...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.97.8.3977